Scientists Look For Path-Breaking Answers On Longevity In The Genome Of 115-Years Old Woman
Scientists have mapped the entire DNA sequence of a woman who lived up to a healthy 115 years.[1] This woman, who was the oldest known person recorded until date, lived a good life right until her death. She donated her body to science, which made it possible to research her genome in the hope that this would unlock the mystery of longevity in human beings.
What motivated the research was not only the highly advanced age of this woman at the time of death, but the fact that her body (now referred to as W115) showed no signs of vascular disease or dementia. Scientists are studying her brain, body organs and have mapped her DNA in search of answers.
The medical history of this woman reveals that she had been born prematurely and at that time there had been little hope that she would pull through. Fortunately for her and humanity, she did live a very long and healthy life. She died of stomach tumor – as revealed by post-mortem examination. She was treated successfully for breast cancer at the age of 100.
What makes this woman amazing and interesting for science is that her body did not show any signs of plaque formation in the arteries (atherosclerosis), which is normally associated with senior years – and lead to dementia. In fact, this woman underwent a neuro-psychological examination at the age of 113 when it was found that her mental capacity (alertness) was as good (if not better) as that of a 65-67 year old.
Scientists hope that W115 genome would reveal path-breaking answers on longevity and good health – especially in context of cardiovascular disease (CVD) – which is presently the top killer in the USA[2] and most parts of the world.
[1] BBC. News Health – DNA sequenced of woman who lived 115, by Helen Briggs, Health Editor, BBC News website. 14 October 2011
[2] CDC. Center for Disease Control and Prevention – FastStats – Leading Causes of Death